A fluoroquinolone antibiotic
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Gatifloxacin

Item No. 14290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
CAS Number
112811-59-3
Synonyms
  • AM1155
  • BMS 206584-01
  • PD 135432
Molecular Formula
C19H22FN3O4
Formula Weight
375.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 1 mg/ml with warming
λmax
216, 234, 297, 325, 334 nm
SMILES
CC1NCCN(C2=C(OC)C(N(C3CC3)C=C(C(O)=O)C4=O)=C4C=C2F)C1
InChi Code
InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChi Key
XUBOMFCQGDBHNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 μg/ml) and topoisomerase IV (IC50 = 13.8 μg/ml).1 It is much less effective against HeLa cell topoisomerase II (IC50 = 265 μg/ml).1 Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia in older adults.2 It remains useful for resolving bacterial conjunctivitis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takei, M., Fukuda, H., Yasue, T., et al. Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob. Agents Chemother. 42(10), 2678-2681 (1998).

    2. Park-Wyllie, L.Y., Juurlink, D.N., Kopp, A., et al. Outpatient gatifloxacin therapy and dysglycemia in older adults. N. Engl. J. Med. 354(13), 1352-1361 (2006).

    3. Cervantes, L.J., and Mah, F.S. Clinical use of gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis. Clin. Ophthalmol. 5(1), 495-502 (2011).