An α7 neuronal nAChR modulator
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PNU 120596

Item No. 14304

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)-urea
CAS Number
501925-31-1
Synonyms
  • NSC 216666
Molecular Formula
C13H14ClN3O4
Formula Weight
311.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS(pH 7.2)(1:1): 0.5 mg/mLDMSO: 20 mg/mL
λmax
210, 254, 298 nm
SMILES
ClC1=C(OC)C=C(OC)C(NC(NC2=NOC(C)=C2)=O)=C1
InChi Code
InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChi Key
CEIIEALEIHQDBX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $96

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    25 mg

    $223

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    50 mg

    $341

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    Product Description

    PNU 120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM).1 It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.1,2 It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hurst, R.S., Hajos, M., Raggenbass, M., et al. A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterization. J. Neurosci. 25(17), 4396-4405 (2015).

    2. Timmermann, D.B., Gronlien, J.H., Kohlhaas, K.L., et al. An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. JPET 323(1), 294-307 (2007).

    3. Kalappa, B.I., Sun, F., Johnson, S.R., et al. A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. Br. J. Pharmacol. 169(8), 1862-1878 (2013).