An irreversible serine protease inhibitor
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AEBSF (hydrochloride)

Item No. 14321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-aminoethyl)-benzenesulfonyl fluoride, monohydrochloride
CAS Number
30827-99-7
Synonyms
  • Pefabloc SC
Molecular Formula
C8H10FNO2S • HCl
Formula Weight
239.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
224, 267, 274 nm
SMILES
NCCC1=CC=C(S(=O)(F)=O)C=C1.Cl
InChi Code
InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key
WRDABNWSWOHGMS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $53

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    100 mg

    $94

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    250 mg

    $194

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    Product Description

    AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins.1 AEBSF can also prevent the activation of the ROS generator, NADPH oxidase.2 At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy.3 AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Powers, J.C., Asgian, J.L., Ekici, Ö., et al. Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem. Rev. 102(12), 4639-4750 (2002).

    2. Diatchuk, V., Lotan, O., Koshkin, V., et al. Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. The Journal of Biological Chemisty 272(20), 13292-13301 (1997).

    3. Saw, S., Kale, S.L., and Arora, N. Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS One 7(7), e41107 (2012).