A STAT3 inhibitor
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S3I-201

Item No. 14336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid
CAS Number
501919-59-1
Synonyms
  • NSC 74859
Molecular Formula
C16H15NO7S
Formula Weight
365.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 16 mg/ml
λmax
219, 268, 309 nm
SMILES
OC(C1=C(O)C=C(NC(COS(C2=CC=C(C)C=C2)(=O)=O)=O)C=C1)=O
InChi Code
InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChi Key
HWNUSGNZBAISFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $70

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    10 mg

    $129

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    25 mg

    $268

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    50 mg

    $369

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    Product Description

    S3I-201 is an inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription. It can suppress IL-6-induced phosphorylation of STAT3 in T cells with an IC50 value of 38 μM.1 Inhibiting STAT3 activation with 10 μM S3I-201 was demonstrated to be protective against angiotensin II-induced oxidative stress, endothelial dysfunction, and hypertension in two different models of vascular disease.2 At 10 μM, S3I-201 has also been used as a means to regress cardiac hypertrophy by inhibiting collagen biosynthesis and decreasing atrial natriuretic factor and β-myosin heavy chain in an in vitro model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, S., Zheng, M., Kibe, R., et al. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. The FASEB Journal 25(7), 2387-2398 (2011).

    2. Johnson, A.W., Kinzenbaw, D.A., Modrick, M.L., et al. Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension. Hypertension 61(2), 437-442 (2013).

    3. Mir, S.A., Chatterjee, A., Mitra, A., et al. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. The Journal of Biological Chemisty 287(4), 2666-2677 (2012).