A polycationic dye that blocks Ca2+ release
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ruthenium Red

Item No. 14339

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
11103-72-3
Synonyms
  • Ammoniated Ruthenium Oxychloride
  • C.I. 77800
Molecular Formula
H42N14O2Ru3 • 6Cl
Formula Weight
786.4
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
[Ru+2]O[Ru+2]O[Ru+2].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
InChi Code
InChI=1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
InChi Key
ZXYSDUPLHOJIOR-UHFFFAOYSA-H
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $40

    Add

    250 mg

    $69

    Add

    500 mg

    $86

    Add

    1 g

    $116

    Add
    Product Description

    Ruthenium red is a polycationic dye that inhibits sarcoplasmic reticulum Ca2+ release, blocks Ca2+ uptake and release from mitochondria, and prevents Ca2+ release from ryanodine-sensitive intracellular stores in skeletal and cardiac muscle (Kis = 16 nM - 5.9 μM, depending on Ca2+ concentration).1 Additionally, ruthenium red binds to anionic sites of cellular components, predominantly to surface glycoconjugates, and can be used as a marker of negative binding sites related to cellular transport, barrier, or receptor functions.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, L., Tripathy, A., Pasek, D.A., et al. Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. The Journal of Biological Chemisty 274(46), 32680-32691 (1999).

    2. El-Saggan, A.H., and Uhrík, B. Improved staining of negative binding sites with ruthenium red on cryosections of frozen cells. Gen. Physiol. Biophys. 21(4), 457-461 (2002).

    Product Citations

    Han, H., Chou, C.C., Li, R., et al. Chalcomoracin is a potent anticancer agent acting through triggering oxidative stress via a mitophagy- and paraptosis-dependent mechanism. Sci. Rep. 8(1), 9566 (2018).

    McDougle, D.R., Watson, J.E., Abdeen, A.A., et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc. Natl. Acad. Sci. USA 114(30), E6034-E6043 (2017).