Yangonin

Yangonin is a natural kavalactone from the kava plant, P. methysticum¹. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABA_A at 1.0 µM. Yangonin also binds the central cannabinoid (CB₁) receptor with a K_i value of 0.72 µM.² Yangonin blocks the activation of NF-κB by TNF-α.³ It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC₅₀s = 15-59 mg/ml).⁴

WARNING This product is not for human or veterinary use.

1. Boonen, G., and Häberlein, H. Influence of genuine kavapyrone enantiomers on the GABA_A binding site. Planta Med. 64(6), 504-506 (1998).

2. Ligresti, A., Villano, R., Allará, M., et al. Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB₁ receptor ligand. Pharmacol. Res. 66(2), 163-169 (2012).

3. Ma, J., Liang, H., Jin, H.R., et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J. Pharmacol. Sci. 118(4), 447-454 (2012).

4. Zhongbo, L., U-Syn, H., Ke, Y., et al. Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway. J. Biomed. Res. 31(5), 408-418 (2017).