An Hsp70 inhibitor
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MKT-077

Item No. 14395

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride
CAS Number
147366-41-4
Synonyms
  • FJ-776
Molecular Formula
C21H22N3OS2 • Cl
Formula Weight
432.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
328, 385, 497 nm
SMILES
CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C\C4=CC=CC=[N+]4CC)=O.[Cl-]
InChi Code
InChI=1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;
InChi Key
VSKYOTRJSLYFHX-UXJRWBAGSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.1 It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Srinivasan, S.R., Connarn, J., et al. Analogs of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents. ACS Med. Chem. Lett. 4(11), (2013).

    2. Rousaki, A., Miyata, Y., Jinwal, U.K., et al. Allosteric drugs: The interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J. Mol. Biol. 411(3), 614-632 (2011).

    3. Wadhwa, R., Sugihara, T., Yoshida, A., et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60(24), 6818-6821 (2000).