An S1P1 agonist
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CS 2100

Item No. 14396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
CAS Number
913827-99-3
Molecular Formula
C25H23N3O4S
Formula Weight
461.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CCC1=C(SC(CN2CC(C(O)=O)C2)=C1)C3=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N3
InChi Code
InChI=1S/C25H23N3O4S/c1-2-16-12-21(15-28-13-18(14-28)25(29)30)33-22(16)23-26-24(32-27-23)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h3-12,18H,2,13-15H2,1H3,(H,29,30)
InChi Key
DWVJASHDNJMDNH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $207

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    25 mg

    $382

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    50 mg

    $654

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    Product Description

    CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist.1,2 It selectively induces GTPγS binding in CHO-K1 cells expressing human or rat S1P1 (EC50s = 4 and 1.5 nM, respectively) over those expressing human or rat S1P3 (EC50s = >20 and 7.4 µM, respectively).1 CS 2100 (0.1 and 1 mg/kg) transiently reduces blood lymphocyte levels in rats with the levels returning to baseline within 24-48 hours. It reduces hind paw volume in a rat model of adjuvant-induced arthritis (ID50 = 0.44 mg/kg). CS 2100 (0.3 and 1 mg/kg) also decreases severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, T., Asano, M., Sekiguchi, Y., et al. Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg. Med. Chem. Lett. 22(4), 1788-1792 (2012).

    2. Nakamura, T., Asano, M., Sekiguchi, Y., et al. Synthesis and evaluation of CS-2100, a potent, orally active and S1P3- sparing S1P1 agonist. Eur. J. Med. Chem. 51, 92-98 (2012).