A stable, isosteric analog of PGE2
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9-deoxy-9-methylene Prostaglandin E2

Item No. 14410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S-dihydroxy-9-methylene-prosta-5Z,13E-dien-1-oic acid
CAS Number
61263-32-9
Synonyms
  • 9-deoxy-9-methylene PGE2
Molecular Formula
C21H34O4
Formula Weight
350.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](C/C=C\CCCC(O)=O)C(C1)=C
InChi Code
InChI=1S/C21H34O4/c1-3-4-7-10-17(22)13-14-19-18(16(2)15-20(19)23)11-8-5-6-9-12-21(24)25/h5,8,13-14,17-20,22-23H,2-4,6-7,9-12,15H2,1H3,(H,24,25)/b8-5-,14-13+/t17-,18-,19+,20+/m0/s1
InChi Key
VKEJXDXJUFQESA-DLMPNJEASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

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    10 mg

    $633

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    Product Description

    9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 (Item No. 14010). 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bundy, G.L., Kimball, F.A., Robert, A., et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv. Prostaglandin Thromboxane Res. 6, 355-363 (1980).