Inhibitor of caspase-3
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Z-DEVD-FMK

Item No. 14414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester
CAS Number
210344-95-9
Molecular Formula
C30H41FN4O12
Formula Weight
668.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
O=C(N[C@@H](CC(OC)=O)C(N[C@@H](CCC(OC)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(OC)=O)C(CF)=O)=O)=O)=O)OCC1=CC=CC=C1
InChi Code
InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChi Key
GBJVAVGBSGRRKN-JYEBCORGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $123

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    1 mg

    $231

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    5 mg

    $902

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    Product Description

    Z-DEVD-FMK is a cell-permeable irreversible inhibitor of caspase-3 (IC50 = 130 nM).1,2 It potently inhibits apoptosis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brockstedt, E., Rickers, A., Kostka, S., et al. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of Biological Chemisty 273(43), 28057-28064 (1998).

    2. Lee, J., and Bogyo, M. Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem. Biol. 5(2), 233-243 (2010).

    3. Kugawa, F., Ueno, A., and Aoki, M. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol. Pharm. Bull. 23(8), 930-935 (2000).