A nucleoside analog with diverse biological activities
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Cordycepin

Item No. 14426

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3'-deoxy-adenosine
CAS Number
73-03-0
Synonyms
  • 3'-Deoxyadenosine
  • NSC 63984
  • NSC 401022
Molecular Formula
C10H13N5O3
Formula Weight
251.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
210, 260 nm
SMILES
OC[C@@H]1C[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1
InChi Code
InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
InChi Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Origin
Fungus/Cordyceps militaris
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities.1,2,3,4,5 Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis.2 It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells.3 Cordycepin (0.1-1 mg/ml) is active against B. subtilis.1 It increases IL-10 secretion and mRNA expression in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 24 µg/ml.4 Cordycepin (1 mg/kg per day) increases survival of mice infected with C. albicans or C. krusei.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cunningham, K.G., Manson, W., Spring, F.S., et al. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 166(4231), 949 (1950).

    2. Wong, Y.Y., Moon, A., Duffin, R., et al. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. The Journal of Biological Chemisty 285(4), 2610-2621 (2010).

    3. Cory, J.G., Suhadolnik, R.J., Resnick, B., et al. Incorporation of cordycepin (3'-deoxyadenosine) into ribonucleic acid and deoxyribonucleic acid of human tumor cells. Biochim. Biophys. Acta 103(4), 646-653 (1965).

    4. Zhou, X., Meyer, C.U., Schmidtke, P., et al. Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. Eur. J. Pharmacol. 453(2-3), 309-317 (2002).

    5. Sugar, A.M., and McCaffrey, R.P. Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob. Agents Chemother. 42(6), 1424-1427 (1998).