An inhibitor of poly(ADP-ribose) polymerases
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Isomer(s)
363762,8-Quinolinediol
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1,5-Isoquinolinediol

Item No. 14438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-1(2H)-isoquinolinone
CAS Number
5154-02-9
Synonyms
  • 1,5-Dihydroxyisoquinoline
  • NSC 65585
Molecular Formula
C9H7NO2
Formula Weight
161.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
OC1=C2C(C(NC=C2)=O)=CC=C1
InChi Code
InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChi Key
LFUJIPVWTMGYDG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    25 mg

    $86

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    100 mg

    $228

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    Product Description

    1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM).1 It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death.2,3,4 This compound can be used with cells in culture and in animals.3,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Banasik, M., Komura, H., Shimoyama, M., et al. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. The Journal of Biological Chemisty 267(3), 1569-1575 (1992).

    2. Ruscetti, T., Lehnert, B.E., Halbrook, J., et al. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. The Journal of Biological Chemisty 273(23), 14461-14467 (1998).

    3. Chatterjee, P.K., Zacharowski, K., Cuzzocrea, S., et al. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. The FASEB Journal 14(5), 641-651 (2000).

    4. Bowes, J., McDonald, M.C., Piper, J., et al. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. Cardiovasc. Res. 41(1), 126-134 (1999).

    5. Byun, J.Y., Kim, M.J., Eum, D.Y., et al. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Mol. Pharmacol. 76(4), 734-744 (2009).

    6. Kang, Y.H., Yi, M.J., Kim, M.J., et al. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: Reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Res. 64(24), 8960-8967 (2004).