An inhibitor of calmodulin
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Calmidazolium (chloride)

Item No. 14442

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolium, monochloride
CAS Number
57265-65-3
Synonyms
  • R 24571
Molecular Formula
C31H23Cl6N2O • Cl
Formula Weight
687.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
SMILES
ClC1=CC=C(C(N2C=[N+](CC(OCC3=CC=C(Cl)C=C3Cl)C4=CC=C(Cl)C=C4Cl)C=C2)C5=CC=C(Cl)C=C5)C=C1.[Cl-]
InChi Code
InChI=1S/C31H23Cl6N2O.ClH/c32-23-6-1-20(2-7-23)31(21-3-8-24(33)9-4-21)39-14-13-38(19-39)17-30(27-12-11-26(35)16-29(27)37)40-18-22-5-10-25(34)15-28(22)36;/h1-16,19,30-31H,17-18H2;1H/q+1;/p-1
InChi Key
YGEIMSMISRCBFF-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $143

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    Product Description

    Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively).1 Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 µM, respectively).1 It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 µM).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gietzen, K. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem. J. 216(3), 611-616 (1983).

    2. Harper, J.L., and Daly, J.W. Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem. Pharmacol. 60(3), 317-324 (2000).

    3. Peppiatt, C.M., Holmes, A.M., Seo, J.T., et al. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem. J. 381(3), 929-939 (2004).