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RH-34

Item No. 14445

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-[[(2-methoxyphenyl)methyl]amino]ethyl]-2,4(1H,3H)-quinazolinedione
CAS Number
1028307-48-3
Molecular Formula
C18H19N3O3
Formula Weight
325.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
219, 278, 312 nm
SMILES
O=C(C1=CC=CC=C1N2)N(CCNCC3=C(OC)C=CC=C3)C2=O
InChi Code
InChI=1S/C18H19N3O3/c1-24-16-9-5-2-6-13(16)12-19-10-11-21-17(22)14-7-3-4-8-15(14)20-18(21)23/h2-9,19H,10-12H2,1H3,(H,20,23)
InChi Key
NUAJBITWGGTZCM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ketanserin is a potent antagonist of the serotonin receptor 5-HT2A (Ki = 3.16 nM) that has hypertensive effects in vivo.1,2 RH-34 is a derivative of ketanserin in which the 4-(p-fluorobenzoyl)piperidine group has been replaced with an N-(2-methoxybenzyl) moiety. In phenethylamines, which are 5-HT2A agonists, this addition increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.3 The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonhaus, D.W., Bach, C., DeSouza, A., et al. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: Comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115(4), 622-628 (1995).

    2. van Zwieten, P.A., Blauw, G.J., and van Brummelen, P. The role of 5-hydroxytryptamine and 5-hydroxytryptaminergic mechanisms in hypertension. Br. J. Clin. Pharmacol. 30 (Suppl 1), 69S-74S (1990).

    3. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe3396.51 and Phe3406.52 with superpotent N-benzyl phenethylamine agonists. Mol. Pharm. 70(6), 1956-1965 (2006).