A broad-spectrum tetracycline antibiotic
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Minocycline (hydrochloride hydrate)

Item No. 14454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,12aS)-4,7-bis(dimethylamino)-1,4,4aS,5,5aR,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride, hydrate
Synonyms
  • NSC 141993
Molecular Formula
C23H27N3O7 • HCl [XH2O]
Formula Weight
493.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 1mg/ml*
λmax
257, 342 nm
SMILES
NC(C1=C(O)[C@@H](N(C)C)[C@@]2([H])[C@](C1=O)(O)C(O)=C3C(C4=C(O)C=CC(N(C)C)=C4C[C@@]3([H])C2)=O)=O.Cl.O
InChi Code
InChI=1S/C23H27N3O7.ClH.H2O/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H;1H2/t9-,11-,17-,23-;;/m0../s1
InChi Key
HDRFYBRHRCRYQB-QVVXJPBESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Minocycline is a broad-spectrum tetracycline antibiotic.1 It is active against E. faecium in vitro (MIC = 16 mg/L). Minocycline (20 mg/kg every 12 hours) reduces the number of bacteria in the lung in a mouse model of multidrug resistant A. baumannii-induced pneumonia.2 It reduces spinal cord lesion size and improves hindlimb function post-injury in a mouse model of acute spinal cord injury when administered at an initial dose of 50 mg/kg and subsequent doses of 25 mg/kg per day for 5 days.3 Formulations containing minocycline have been used in the treatment of acne vulgaris.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boukthir, S., Dejoies, L., Zouari, A., et al. In vitro activity of eravacycline and mechanisms of resistance in enterococci. Int. J. Antimicrob. Agents 56(6), 106215 (2020).

    2. Ku, N.S., Lee, S.-H., Lim, Y.-S., et al. In vivo efficacy of combination of colistin with fosfomycin or minocycline in a mouse model of multidrug-resistant Acinetobacter baumannii pneumonia. Sci. Rep. 9(1), 17127 (2019).

    3. Wells, J.E.A., Hurlbert, R.J., Fehlings, M.G., et al. Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain 126(Pt 7), 1628-1637 (2003).