A selective inhibitor of PDE3
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Cilostamide

Item No. 14455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-butanamide
CAS Number
68550-75-4
Synonyms
  • OPC 3689
Molecular Formula
C20H26N2O3
Formula Weight
342.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/ml
λmax
234, 270, 350 nm
SMILES
CN(C(CCCOC1=CC=C(NC(C=C2)=O)C2=C1)=O)C3CCCCC3
InChi Code
InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChi Key
UIAYVIIHMORPSJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $82

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    10 mg

    $154

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    25 mg

    $322

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    Product Description

    Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.1 It is less selective for inhibition of PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 12 to > 300 μM).1 Cilostamide has been shown to inhibit thrombin-induced platelet aggregation with an IC50 value of 1.1 μM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sudo, T., Tachibana, K., Toga, K., et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phophodiesterase isozyme activity. Biochem. Pharmacol. 59(4), 347-356 (2000).