A colorimetric caspase substrate
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Ac-DEVD-pNA

Item No. 14460

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-α-asparagine
CAS Number
189950-66-1
Synonyms
  • Ac-Asp-Glu-Val-Asp-pNA
Molecular Formula
C26H34N6O13
Formula Weight
638.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): 1 mg/ml
SMILES
CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(NC1=CC=C([N+]([O-])=O)C=C1)=O)C(O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C26H34N6O13/c1-12(2)22(25(41)30-18(26(42)43)10-19(34)28-14-4-6-15(7-5-14)32(44)45)31-23(39)16(8-9-20(35)36)29-24(40)17(11-21(37)38)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,34)(H,29,40)(H,30,41)(H,31,39)(H,35,36)(H,37,38)(H,42
InChi Key
DAOMBBSDYYRHPX-ORGXJRBJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    Product Description

    Ac-DEVD-pNA is a para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 µM for caspases-1, -3, -4, -6, and -7, respectively).1 It is not cleaved by caspase-2.1 Cleavage is monitored colorimetrically at 405 nm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272(15), 9677-9682 (1997).