An inhibitor of caspase-3
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Ac-DEVD-CMK

Item No. 14465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
CAS Number
285570-60-7
Synonyms
  • Ac-Asp-Glu-Val-Asp-CMK
  • Caspase-3 Inhibitor III
Molecular Formula
C21H31ClN4O11
Formula Weight
550.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml
SMILES
CC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C21H31ClN4O11/c1-9(2)18(21(37)25-12(6-16(31)32)14(28)8-22)26-19(35)11(4-5-15(29)30)24-20(36)13(7-17(33)34)23-10(3)27/h9,11-13,18H,4-8H2,1-3H3,(H,23,27)(H,24,36)(H,25,37)(H,26,35)(H,29,30)(H,31,32)(H,33,34)/t11-,12-,13-,18-/m0/s1
InChi Key
ATNOUPFYBMVFLD-RSLFNQERSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $417

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    Product Description

    Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.1,2,3 It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.4,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mocanu, M.M., Baxter, G.F., and Yellon, D.M. Caspase inhibition and limitation of myocardial infarct size: Protection against lethal reperfusion injury. Br. J. Pharmacol. 130(2), 197-200 (2000).

    2. Schrantz, N., Blanchard, D.A., Mitenne, F., et al. Manganese induces apoptosis of human B cells: Caspase-dependent cell death blocked by Bcl-2. Cell Death Differ. 6(5), 445-453 (1999).

    3. Thornberry, N.A., and Lazebnik, Y. Caspases: Enemies within. Science 281(5381), 1312-1316 (1998).

    4. Zhang, Y., Wang, H., Li, J., et al. Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J. Neurosci. 24(47), 10616-10627 (2004).