Buthionine Sulfoximine
Item № 14484
CAS № 83730-53-4
Purity ≥98%
250 mg $65.00 $0.00
500 mg $124.00 $0.00
1 g $234.00 $0.00

Pricing updated 2016-05-01. Prices are subject to change without notice.

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  • BSO
  • L-Buthionine-S,R-Sulfoximine
  • NSC 326231

Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH.1,2 Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis.3,4 Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.5

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Technical Information
Formal Name 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
CAS Number 83730-53-4
  • BSO
  • L-Buthionine-S,R-Sulfoximine
  • NSC 326231
Molecular Formula C8H18N2O3S
Formula Weight 222.3
Purity ≥98%
Formulation A crystalline solid
InChI Code 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Reliene, R., and Schiestl, R.H. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis 27(2) 240-244 (2006).

2. Griffith, O.W. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257(22) 13704-13712 (1982).

3. Takahashi, K., Tatsunami, R., Oba, T., et al. Buthionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cells. Biol Pharm Bull 33(4) 556-560 (2010).

4. Han, Y.H., Moon, H.J., You, B.R., et al. The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. Int J Mol Med 24(2) 261-268 (2009).

5. Lewis-Wambi, J.S., Kim, H.R., Wambi, C., et al. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res 10(6) (2008).

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