A muscarinic acetylcholine receptor agonist
Related Products
Labeled Version(s)
29078(+)-Pilocarpine-d3 (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(+)-Pilocarpine (hydrochloride)

Item No. 14487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride
CAS Number
54-71-7
Synonyms
  • NSC 5746
Molecular Formula
C11H16N2O2 • HCl
Formula Weight
244.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
215 nm
SMILES
CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O.Cl
InChi Code
InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
InChi Key
RNAICSBVACLLGM-GNAZCLTHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $41

    Add

    1 g

    $53

    Add

    5 g

    $239

    Add

    10 g

    $436

    Add
    Product Description

    (+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 μM, respectively).1 It induces salivary secretion in rats when administered intraperitoneally at a dose of 1 mg/kg.2 Topical administration of (+)-pilocarpine inhibits methylcellulose-induced increases in intraocular pressure in rabbits in a dose-dependent manner.3 (+)-Pilocarpine is a chemoconvulsant that has been used in the generation of temporal lobe epilepsy animal models.4,5,6 Formulations containing (+)-pilocarpine have been used in the treatment of elevated intraocular pressure and dry mouth.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vanderheyden, P., Gies, J.-P., Ebinger, G., et al. Human M1-, M2- and M3-muscarinic cholinergic receptors: Binding characteristics of agonists and antagonists. J. Neurol. Sci. 97(1), 67-80 (1990).

    2. Renzi, A., Colombari, E., Mattos Filho, T.R., et al. Involvement of the central nervous system in the salivary secretion induced by pilocarpine in rats. J. Dent. Res. 72(11), 1481-1484 (1993).

    3. Lorenzetti, O.J. The influence of epinephrine and pilocarpine upon intraocular pressure following single and combination installation. Ophthal. Res. 2(6), 328-336 (1971).

    4. Kokate, T.G., Cohen, A.L., Karp, E., et al. Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. Neuropharmacology 35(8), 1049-1056 (1996).

    5. Ma, L., Wang, L., Yang, F., et al. Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy. CNS Neurosci. Ther. 20(10), 905-915 (2014).

    6. Smolders, I., Khan, G.M., Manil, H., et al. NMDA receptor-mediated pilocarpine-induced seizures: Characterization in freely moving rats by microdialysis. Br. J. Pharmacol. 121(6), 1171-1179 (1997).

    Product Citations

    Lewis, V., Bonniwell, E.M., Lanham, J.K., et al. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. Cell Rep. 42(3), 112203 (2023).