N-Phenylacetyl-L-Prolylglycine ethyl ester

N-Phenylacetyl-L-prolylglycine ethyl ester is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models (0.01-0.8 mg/kg) by a mechanism similar to other related racetam compounds.¹ It can rescue neuroblastoma SH-SY5Y cells from amyloid-induced cytotoxicity, indicating a potential application in the treatment of neurodegenerative diseases.² It also demonstrates antioxidant and anti-inflammatory effects, which have been examined in the context of an anti-diabetic agent.³ This compound was recently identified in illegal designer herbal products distributed in Japan and is intended for research and forensic purposes only.⁴

WARNING This product is not for human or veterinary use.

1. Gudasheva, T.A., Voronins, T.A., Ostrovskaya, R.U., et al. Synthesis and antiamnesic activity of a series of IV-acylprolyl-containing dipeptides. Eur. J. Med. Chem. 31(2), 151-157 (1996).

2. Jia, X., Gharibyan, A.L., Öhman, A., et al. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. J. Mol. Biol. 414(5), 699-712 (2011).

3. Ostrovskaya, R.U., Ozerova, I.V., Gudascheva, T.A., et al. Efficiency of noopept in streptozotocin-induced diabetes in rats. Bull. Exp. Biol. Med. 154(3), 334-338 (2013).

4. Uchiyama, N., Matsuda, S., Kawamura, M., et al. Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C₆) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-α-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products. Forensic Toxicol. 32, 9-18 (2014).