An inhibitor of PARP
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NU 1025

Item No. 14534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-hydroxy-2-methyl-4(3H)-quinazolinone
CAS Number
90417-38-2
Synonyms
  • NSC 696807
Molecular Formula
C9H8N2O2
Formula Weight
176.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 11 mg/mlEthanol: 0.11 mg/ml
λmax
236, 282, 318 nm
SMILES
CC(N1)=NC2=C(O)C=CC=C2C1=O
InChi Code
InChI=1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChi Key
YJDAOHJWLUNFLX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $35

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    5 mg

    $128

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    25 mg

    $376

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    50 mg

    $709

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    Cayman Chemical
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    Product Description

    NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).1 It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs.2,3 NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffin, R.J., Srinivasan, S., Bowman, K., et al. Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J. Med. Chem. 41(26), 5247-5256 (1998).

    2. Bowman, K.J., White, A., Golding, B.T., et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br. J. Cancer 78(10), 1269-1277 (1998).

    3. Delaney, C.A., Wang, L.Z., Kyle, S., et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin. Cancer Res. 6(7), 2860-2867 (2000).

    4. Kumala, S., Fujarewicz, K., Jayaraju, D., et al. Repair of DNA strand breaks in a minichromosome in vivo: Kinetics, modeling, and effects of inhibitors. PLoS One 8(1), (2013).