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D-AP5

Item № 14539
CAS № 79055-68-8
Purity ≥95%
product image
                (CAS 79055-68-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $45.00 0.00
     10 mg $81.00 0.00
     50 mg $360.00 0.00
     100 mg $540.00 0.00

Pricing updated 2019-04-23. Prices are subject to change without notice.

Description
Synonyms
  • D-2-Amino-5-Phosphonovaleric acid
  • D-APV

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.1 Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.1 AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.2

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Technical Information
Formal Name
5-phosphono-D-norvaline
CAS Number
79055-68-8
Synonyms
  • D-2-Amino-5-Phosphonovaleric acid
  • D-APV
Molecular Formula
C5H12NO5P
Formula Weight
197.1
Purity
≥95%
Formulation
A crystalline solid
SMILES
OP(CCC[C@H](C(O)=O)N)(O)=O
InChI Code
InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
InChI Key
VOROEQBFPPIACJ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations Br. J. Pharmacol. 75(1), 65-75 (1982).

2. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5 J. Neurosci. 9(9), 3040-3057 (1989).

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