An S1P4 agonist
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CYM 50260

Item No. 14560

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)-pyridine
CAS Number
1355026-60-6
Molecular Formula
C14H11Cl3FNO2
Formula Weight
350.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
ClC1=CC(Cl)=C(OCCOC2=CC=C(CF)N=C2Cl)C=C1
InChi Code
InChI=1S/C14H11Cl3FNO2/c15-9-1-3-12(11(16)7-9)20-5-6-21-13-4-2-10(8-18)19-14(13)17/h1-4,7H,5-6,8H2
InChi Key
FHPOTBQOUBMMCI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $152

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    10 mg

    $208

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    25 mg

    $439

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    Product Description

    CYM 50260 is an agonist of sphingosine-1-phosphate receptor 4 (S1P4).1 It induces gene transcription in a reporter assay using U2OS cells expressing human S1P4 (EC50 = 45 nM). CYM 50260 (25 µM) inhibits collagen-induced increases in PDGF-AB secretion from, and phosphorylated heat shock protein 27 (Hsp27) levels in, isolated human platelets.2 It also inhibits collagen-induced increases in platelet aggregate size.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guerrero, M., Urbano, M., Zhao, J., et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg. Med. Chem. Lett. 22(1), 537-542 (2012).

    2. Onuma, T., Tanabe, K., Kito, Y., et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb. Res. 156, 91-100 (2017).