A direct activator of Bax
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BAM7

Item No. 14566

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-ethoxyphenyl)hydrazone]
CAS Number
331244-89-4
Synonyms
  • Bax Activator Molecule 7
Molecular Formula
C21H19N5O2S
Formula Weight
405.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2)(1:3): 0.33 mg/mlDMSO: 2 mg/ml
λmax
236, 263, 426 nm
SMILES
CCOC1=CC=CC=C1N/N=C2C(C)=NN(C3=NC(C4=CC=CC=C4)=CS3)C\2=O
InChi Code
InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
InChi Key
KOCVKGYKBLJEPK-LYBHJNIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    BAM7 is a direct activator of Bax (EC50 = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax.1 It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell death in mouse embryo fibroblasts.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gavathiotis, E., Reyna, D.E., Bellairs, J.A., et al. Direct and selective small-molecule activation of proapoptotic BAX. Nat. Chem. Biol. 8(7), 639-645 (2012).