An EP2 and EP3 receptor agonist
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11-deoxy-16,16-dimethyl Prostaglandin E2

Item No. 14570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15R-hydroxy-16,16-dimethyl-9-oxo-prosta-5Z,13E-dien-1-oic acid
CAS Number
53658-98-3
Synonyms
  • 11-deoxy-16,16-dimethyl PGE2
Molecular Formula
C22H36O4
Formula Weight
364.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)CC1
InChi Code
InChI=1S/C22H36O4/c1-4-5-16-22(2,3)20(24)15-13-17-12-14-19(23)18(17)10-8-6-7-9-11-21(25)26/h6,8,13,15,17-18,20,24H,4-5,7,9-12,14,16H2,1-3H3,(H,25,26)/b8-6-,15-13+/t17-,18-,20-/m1/s1
InChi Key
LLVVDFDWPQHXBA-QEJIITRLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    11-deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors.1 It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively.2 It is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parrott, R.F., and Vellucci, S.V. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res. Bull. 41(2), 97-103 (1996).

    2. Lippmann, W. Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-Hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids. Prostaglandins 7(3), 231-246 (1974).

    3. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv. Prostaglandin Thromboxane Res. 7, 969-980 (1980).