An inhibitor of glutamatergic transmission
Related Products
Alternative(s)
35833Riluzole
Metabolite(s)
33999N-hydroxy Riluzole
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Riluzole (hydrochloride)

Item No. 14577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(trifluoromethoxy)-2-benzothiazolamine, monohydrochloride
CAS Number
850608-87-6
Synonyms
  • PK 26124
Molecular Formula
C8H5F3N2OS • HCl
Formula Weight
270.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mLEthanol:PBS (pH7.2)(1:20): 0.04 mg/mLWater: Soluble
SMILES
NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2.Cl
InChi Code
InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
InChi Key
QEAOELIJQRYJJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $41

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    50 mg

    $186

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    Product Description

    Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM).1 Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg.1 Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheah, B.C., Vucic, S., Krishnan, A.V., et al. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr. Med. Chem. 17(18), 1942-1959 (2010).