A non-NMDA glutamate receptor antagonist
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DNQX

Item No. 14583

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-6,7-dinitro-2,3-quinoxalinedione
CAS Number
2379-57-9
Synonyms
  • 6,7-Dinitroquinoxaline-2,3-dione
  • FG 9041
Molecular Formula
C8H4N4O6
Formula Weight
252.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
273, 334 nm
SMILES
O=C1C(NC2=CC([N+]([O-])=O)=C([N+]([O-])=O)C=C2N1)=O
InChi Code
InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChi Key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $41

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    25 mg

    $71

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    50 mg

    $128

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    100 mg

    $235

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    Product Description

    DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC50 = 40 μM for NMDA receptors).1,2,3 This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Armstrong, N., and Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28(1), 165-181 (2000).

    2. Honoré, T., Davies, S.N., Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988).

    3. Lee, S.H., Govindaiah, G., and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J. Neurophysiol. 103(4), 1728-1734 (2010).

    4. Muller, D., Joly, M., and Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242(4886), 1694-1697 (1988).