A small molecule inhibitor of STAT3
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Stattic

Item No. 14590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-nitro-1,1-dioxide-benzo[b]thiophene
CAS Number
19983-44-9
Synonyms
  • STAT3 Inhibitor V
Molecular Formula
C8H5NO4S
Formula Weight
211.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
214, 308 nm
SMILES
O=S1(C2=CC([N+]([O-])=O)=CC=C2C=C1)=O
InChi Code
InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChi Key
ZRRGOUHITGRLBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $63

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    25 mg

    $129

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    50 mg

    $229

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    Cayman Chemical
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    Product Description

    Stattic is a small molecule inhibitor of STAT3.1 It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).1 At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schust, J., Sperl, B., Hollis, A., et al. Stattic: A small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 13(11), 1235-1242 (2006).

    Product Citations

    Lyu, H., Petukhov, P.A., Banta, P.R., et al. Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis. ACS Infect. Dis. 6(3), 393-405 (2020).