A potent agonist of PAR2
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2-furoyl-LIGRLO amide (trifluoroacetate salt)

Item No. 14594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide, trifluoroacetate
Molecular Formula
C36H63N11O8 • XCF3COOH
Formula Weight
778.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCN)C(N)=O)=O)=O)CNC([C@@H](NC([C@@H](NC(C1=CC=CO1)=O)CC(C)C)=O)[C@@H](C)CC)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C36H63N11O8.C2HF3O2/c1-7-22(6)29(47-33(52)26(18-21(4)5)46-34(53)27-13-10-16-55-27)35(54)42-19-28(48)43-24(12-9-15-41-36(39)40)31(50)45-25(17-20(2)3)32(51)44-23(30(38)49)11-8-14-37;3-2(4,5)1(6)7/h10,13,16,20-26,29H,7-9,11-12,14-15,17-19,37H2,1-6H3,(H2,38,49)(H,42,54)(H,43,48)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H4,39,40,41);(H,6,7)/t22-,23-,24-,25-,26-,29-;/m0./s1
InChi Key
GGAPZASUUCRPNF-OIQQVIETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $128

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    Product Description

    2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0).1 It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation of arteries previously contracted with α1 adrenergic receptor agonists.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McGuire, J.J., Saifeddine, M., Triggle, C.R., et al. 2-Furoyl-LIGRLO-amide: A potent and selective proteinase-activated receptor 2 agonist. J. Pharmacol. Exp. Ther. 309(3), 1124-1131 (2004).