A natural lignan with diverse physiological effects
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Isomer(s)
38954Dienestrol
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Honokiol

Item No. 14597

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3',5-di-2-propen-1-yl-[1,1'-biphenyl]-2,4'-diol
CAS Number
35354-74-6
Synonyms
  • NSC 293100
Molecular Formula
C18H18O2
Formula Weight
266.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlEthanol: 33 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
258, 294 nm
SMILES
OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=C(O)C=C2
InChi Code
InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChi Key
FVYXIJYOAGAUQK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $81

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    25 mg

    $190

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    Cayman Chemical
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    Product Description

    Honokiol is a natural product derived from parts of the plant M. grandiflora used in Oriental herbal medicine. It is a lignan that produces diverse therapeutic effects, including acting as an anxiolytic in mice.1 Honokiol also inhibits nuclear factor-κB and phosphoinositide 3-kinase/Akt signaling, preventing inflammation, and interferes with angiogenesis while preventing tumor growth in vivo.2,3,4,5 It also scavenges superoxide and peroxyl radicals.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maruyama, Y., Kuribara, H., Morita, M., et al. Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicine. J. Nat. Prod. 61(1), 135-138 (1998).

    2. Bai, X., Cerimele, F., Ushio-Fukai, M., et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. The Journal of Biological Chemisty 278(37), 35501-35507 (2003).

    3. Ahn, K.S., Sethi, G., Shishodia, S., et al. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol. Cancer Res. 4(9), 621-633 (2006).

    4. Singh, T., and Katiyar, S.K. Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE2-mediated activation of β-catenin signaling. PLoS One 8(4), e60749 (2013).

    5. Kim, B.H., and Cho, J.Y. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol. Sin. 29(1), 113-122 (2008).

    6. Dikalov, S., Losik, T., and Arbiser, J.L. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem. Pharmacol. 76(5), 589-596 (2008).