A dopamine receptor agonist
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Labeled Version(s)
26669Bromocriptine-13C-d3
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Bromocriptine (mesylate)

Item No. 14598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5α)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-errgotaman-3',6',18-trione, monomethanesulfonate
CAS Number
22260-51-1
Synonyms
  • CB-154
Molecular Formula
C32H40BrN5O5 • CH3SO3H
Formula Weight
750.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 5 mg/ml
λmax
304 nm
SMILES
O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@@]3(C(C)C)NC([C@@H](CN(C)[C@]4([H])C5)C=C4C6=C7C5=C(Br)NC7=CC=C6)=O)N([C@H]2CC(C)C)C3=O.CS(=O)(O)=O
InChi Code
InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2
InChi Key
NOJMTMIRQRDZMT-GSPXQYRGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5 receptors, respectively).1 It also binds to the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as α1-adrenergic receptors (Kis = 1.12-4.17 nM).1,2 Bromocriptine (5 mg/kg) restores locomotor activity, without inducing dyskinesia, in a macaque model of Parkinson’s disease induced by MPTP.3 Formulations containing bromocriptine have been used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kvernmo, T., Härtter, S., and Bürger, E. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin. Ther. 28(8), 1065-1078 (2006).

    2. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther. 303(2), 791-804 (2002).

    3. Rouillard, C., Bédard, P.J., and De Paolo, T. Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393. Eur. J. Pharmacol. 185(2-3), 209-215 (1990).

    Product Citations

    Kundu, D., Franchini, L., Hasdemir, H.S., et al. Distinct interactions of cannabinol and its cytochrome P450-generated metabolites with receptors and sensory neurons. J. Med. Chem. 68(13), 13935-13953 (2025).