A noncompetitive nicotinic antagonist
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Mecamylamine (hydrochloride)

Item No. 14602

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,2,3,3-tetramethyl-bicyclo[2.2.1]heptan-2-amine, monohydrochloride
CAS Number
826-39-1
Synonyms
  • Inversine
Molecular Formula
C11H21N • HCl
Formula Weight
203.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
C[C@]1(NC)C(C)(C)[C@@H]2CC[C@H]1C2.Cl
InChi Code
InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m1./s1
InChi Key
PKVZBNCYEICAQP-GITWGATASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $73

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    25 mg

    $167

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    50 mg

    $306

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    Product Description

    Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).1 Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Papke, R.L., Sanberg, P.R., and Shytle, R.D. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J. Pharmacol. Exp. Ther. 297(2), 646-656 (2001).

    2. Damaj, M.I., Flood, P., Ho, K.K., et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivity. J. Pharmacol. Exp. Ther. 312(2), 780-785 (2005).

    3. Mineur, Y.S., and Picciotto, M.R. Nicotine receptors and depression: Revisiting and revising the chlorinergic hypothesis. Trends Pharmacol. Sci. 31(12), 580-586 (2010).

    Product Citations

    Isotani, R., Igarashi, M., Miura, M., et al. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway. Elife 13, RP95267 (2025).