An AMPA receptor antagonist
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Philanthotoxin 74 (hydrochloride)

Item No. 14607

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-αS-[(1-oxobutyl)amino]-benzenepropanamide, dihydrochloride
CAS Number
1227301-51-0
Synonyms
  • PhTx-74
Molecular Formula
C24H42N4O3 • 2HCl
Formula Weight
507.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 100 mM
SMILES
OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl
InChi Code
InChI=1S/C24H42N4O3.2ClH/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25;;/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30);2*1H/t22-;;/m0../s1
InChi Key
HWTJQQMIKVJWLH-IKXQUJFKSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    10 mg

    $186

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    Product Description

    Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.1 PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nilsen, A., and England, P.M. A subtype-selective, use-dependent inhibitor of native AMPA receptors. J. Am. Chem. Soc. 129(16), 4902-4903 (2007).

    2. Kromann, H., Krikstolaityte, S., Andersen, A.J., et al. Solid-phase synthesis of polyamine toxin analogues: Potent and selective antagonists of Ca2+-permeable AMPA receptors. J. Med. Chem. 45(26), 5745-5754 (2002).