A potent nicotinic acetylcholine receptor agonist
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(±)-Anatoxin A (fumarate)

Item No. 14609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-ethanone, 2-butenedioate
CAS Number
1219922-30-1
Molecular Formula
C10H15NO • C4H4O4
Formula Weight
281.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 50 mM
SMILES
O=C(/C=C/C(O)=O)O.CC(C1=CCCC2NC1CC2)=O
InChi Code
InChI=1S/C10H15NO.C4H4O4/c1-7(12)9-4-2-3-8-5-6-10(9)11-8;5-3(6)1-2-4(7)8/h4,8,10-11H,2-3,5-6H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChi Key
ZJSIFVODFDHYJU-WLHGVMLRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $269

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    Product Description

    (±)-Anatoxin A is a bicyclic amine isolated from the blue-green alga A. aquae that displays high affinity for nicotinic acetylcholine receptors (Kd = 0.1-0.2 μM).1 It binds α4β2- and α7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 μM, respectively, and stimulates [3H]-dopamine release from striatal synaptosomes with an EC50 value of 134 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aronstam, R.S., and Witkop, B. Anatoxin-a interactions with cholinergic synaptic molecules. Proc. Natl. Acad. Sci. USA 78(7), 4639-4643 (1981).

    2. Sharples, C.G., Kaiser, S., Soliakov, L., et al. UB-165: A novel nicotinic agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes. J. Neurosci. 20(8), 2783-2791 (2000).