A cholesterol synthesis inhibitor
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AY 9944

Item No. 14611

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride
CAS Number
366-93-8
Molecular Formula
C22H28Cl2N2 • 2HCl
Formula Weight
464.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleEthanol: slightly solublePBS (pH 7.2): Slightly soluble
λmax
212 nm
SMILES
ClC1=C(CNCC2CC[C@H](CNCC3=C(Cl)C=CC=C3)CC2)C=CC=C1.Cl.Cl
InChi Code
InChI=1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H/t17-,18?;;
InChi Key
NRVIEWRSGDDWHP-FMQKKFGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $38

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    5 mg

    $110

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    10 mg

    $202

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    25 mg

    $454

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    Product Description

    AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Item No. 14612) to cholesterol.1,2 Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused.3 AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.2,4 However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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