A non-NMDA glutamate receptor antagonist
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CNQX

Item No. 14618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile
CAS Number
115066-14-3
Synonyms
  • 6-cyano-7-Nitroquinoxaline-2,3-dione
  • FG 9065
Molecular Formula
C9H4N4O4
Formula Weight
232.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
217, 275, 315 nm
SMILES
O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
InChi Code
InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChi Key
RPXVIAFEQBNEAX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $94

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    25 mg

    $203

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    50 mg

    $322

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    Product Description

    CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors).1,2 This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Honoré, T., Davies, S.N., Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988).

    2. Lee, S.H., Govindaiah, G., and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J. Neurophysiol. 103(4), 1728-1734 (2010).