A neuroprotective AChE inhibitor
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(−)-Huperzine A

Item No. 14620

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
CAS Number
102518-79-6
Synonyms
  • Hup A
  • (−)-Selagine
Molecular Formula
C15H18N2O
Formula Weight
242.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlMethanol: 1 mg/ml
λmax
231, 313 nm
SMILES
N[C@@]1(CC(C)=C2)C(C=CC3=O)=C(N3)C[C@@]2([H])/C1=C\C
InChi Code
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
InChi Key
ZRJBHWIHUMBLCN-YQEJDHNASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    Product Description

    (−)-Huperzine A is a natural sesquiterpene alkaloid first isolated from Huperzia, a club moss used in Chinese medicine for its neuroprotective activity.1 It inhibits acetylcholinesterase (AChE) in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals.1 (−)-Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer’s disease.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tun, M.K.M., and Herzon, S.B. The pharmacology and therapeutic potential of (−)-huperzine A. J. Exp. Pharmacol. 4, 113-123 (2012).

    2. Yang, G., Wang, Y., Tian, J., et al. Huperzine A for Alzheimer’s disease: A systematic review and meta-analysis of randomized clinical trials. PLoS One 8(9), (2013).