A positive allosteric modulator of GluA2
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CMPDA

Item No. 14626

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide
CAS Number
380607-77-2
Molecular Formula
C16H28N2O4S2
Formula Weight
376.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMSO: 30mg/mLEthanol: 30mg/mLPBS (pH 7.2): 10mg/mL
λmax
219 nm
SMILES
O=S(NCCC1=CC=C(CCNS(C(C)C)(=O)=O)C=C1)(C(C)C)=O
InChi Code
InChI=1S/C16H28N2O4S2/c1-13(2)23(19,20)17-11-9-15-5-7-16(8-6-15)10-12-18-24(21,22)14(3)4/h5-8,13-14,17-18H,9-12H2,1-4H3
InChi Key
FHLGMMYEKXPVSC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2.1 It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 μM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Timm, D.E., Benveniste, M., Weeks, A.M., et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol. Pharmacol. 80(2), 267-280 (2011).