An intermediate in the synthesis of phosphatidylcholine
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Citicoline (sodium salt)

Item No. 14629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P'-[2-(trimethylammonio)ethyl] ester-cytidine 5'-(trihydrogen diphosphate)-inner, monosodium salt
CAS Number
33818-15-4
Synonyms
  • Cytidine 5'-diphosphocholine
  • Flussorex
  • Gerolin
  • Logan
  • Neurotron
  • Sinkron
Molecular Formula
C14H25N4O11P2 • Na
Formula Weight
510.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
274 nm
SMILES
O=P(OP(OCC[N+](C)(C)C)([O-])=O)([O-])OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)[C@H](O)[C@@H]1O.[Na+]
InChi Code
InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1
InChi Key
YWAFNFGRBBBSPD-OCMLZEEQSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cells.1 It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicholine demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders.2 Exogenous administration of citicholine to rodents (500 mg/kg i.p. immediately after ischemia and at 3-h reperfusion) has been shown to stimulate the synthesis of phosphatidylcholine, sphingomyelin, and cardiolipin and to attenuate the release of arachidonic acid and the accumulation of ceramide.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McMaster, C.R., and Bell, R.M. Phosphatidylcholine biosynthesis via the CDP-choline pathway in Saccharomyces cerevisiae. The Journal of Biological Chemisty 269(20), 14776-14783 (1994).

    2. Dávalos, A., and Secades, J. Citicoline preclinical and clinical update 2009-2010. Stroke 42(1), 36-39 (2011).

    3. Rao, M., Hatcher, J.F., and Dempsey, R.J. Lipid alterations in transient forebrain ischemia: Possible new mechanisms of CDP-choline neuroprotection. J. Neurochem. 75(6), 2528-2535 (2000).