A microtubule-binding trisubstituted purine
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Myoseverin

Item No. 14642

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2,N6-bis[(4-methoxyphenyl)methyl]-9-(1-methylethyl)-9H-purine-2,6-diamine
CAS Number
267402-71-1
Molecular Formula
C24H28N6O2
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3.3 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 0.11 mg/ml
λmax
231, 262, 285 nm
SMILES
COC1=CC=C(CNC2=NC(NCC3=CC=C(OC)C=C3)=NC4=C2N=CN4C(C)C)C=C1
InChi Code
InChI=1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12,15-16H,13-14H2,1-4H3,(H2,25,26,28,29)
InChi Key
IDCOTQWQVPRTNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $190

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    Product Description

    Myoseverin is a trisubstituted purine which binds microtubules, reversibly altering cellular function.1,2 At 20 μM, it directly binds tubulin and disrupts the structure of the microtubule cytoskeleton, resulting in myotube fission.1 Myoseverin arrests cell cycle in the G2/M phase, followed by DNA synthesis and cell proliferation after removal of the compound.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosania, G.R., Chang, Y.T., Perez, O., et al. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat. Biotechnol. 18(3), 304-308 (2000).

    2. Moon, H.S., Jacobson, E.M., Khersonsky, S.M., et al. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J. Am. Chem. Soc. 124(39), 11608-11609 (2002).