An inhibitor of SIRT2
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JFD00244

Item No. 14648

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-9,10-anthracenedione
CAS Number
96969-83-4
Synonyms
  • BML-266
Molecular Formula
C30H26N2O4
Formula Weight
478.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.3 mg/ml
λmax
226, 258, 596, 642 nm
SMILES
O=C(C1=C2C(NCCC3=CC=C(O)C=C3)=CC=C1NCCC4=CC=C(O)C=C4)C5=C(C=CC=C5)C2=O
InChi Code
InChI=1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2
InChi Key
UUJHFIBEJJLZBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $120

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    Cayman Chemical
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    Product Description

    JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).1 At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiviranta, P.H., Leppänen, J., Kyrylenko, S., et al. N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors. J. Med. Chem. 49(26), 7907-7911 (2006).

    2. Sunami, Y., Araki, M., Hironaka, Y., et al. Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. PLoS One 8(2), 57633 (2013).