A tyrosinase inhibitor
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Aloesin

Item No. 14649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-β-D-glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
CAS Number
30861-27-9
Molecular Formula
C19H22O9
Formula Weight
394.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
215, 245, 253, 295 nm
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](C2=C(OC(CC(C)=O)=CC3=O)C3=C(C)C=C2O)[C@@H]1O
InChi Code
InChI=1S/C19H22O9/c1-7-3-10(22)14(19-17(26)16(25)15(24)12(6-20)28-19)18-13(7)11(23)5-9(27-18)4-8(2)21/h3,5,12,15-17,19-20,22,24-26H,4,6H2,1-2H3/t12-,15-,16+,17-,19+/m1/s1
InChi Key
HKIKAXXIWJHWLY-ZIIYPAMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

    $152

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    5 mg

    $475

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    Product Description

    Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.1 Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.2 The antihyperpigmenting effects of aloesin have been explored in melanocytes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Piao, L.Z., Park, H.R., Park, Y.K., et al. Mushroom tyrosinase inhibition activity of some chromones. Chem. Pharm. Bull. (Tokyo) 50(3), 309-311 (2002).

    2. Yagi, A., and Takeo, S. Anti-inflammatory constituents, aloesin and aloemannan in Aloe species and effects of tanshinon VI in Salvia miltiorrhiza on heart. Yakugaku Zasshi 123(7), 517-532 (2003).

    3. Kim, H., Choi, H.R., Kim, D.S., et al. Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action. Ann. Dermatol. 24(1), 1-6 (2012).