An antibiotic that can induce apoptosis
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Xanthorrhizol

Item No. 14668

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1R)-1,5-dimethyl-4-hexen-1-yl]-2-methyl-phenol
CAS Number
30199-26-9
Molecular Formula
C15H22O
Formula Weight
218.3
Purity
≥97%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleWater: Slightly soluble
λmax
276 nm
SMILES
OC1=C(C)C=CC([C@H](C)CC/C=C(C)/C)=C1
InChi Code
InChI=1S/C15H22O/c1-11(2)6-5-7-12(3)14-9-8-13(4)15(16)10-14/h6,8-10,12,16H,5,7H2,1-4H3/t12-/m1/s1
InChi Key
FKWGCEDRLNNZOZ-GFCCVEGCSA-N
Origin
Plant/Curcuma xanthorrhiza
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $148

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    Product Description

    Xanthorrhizol is a sesquiterpenoid isolated from the rhizome of C. xanthorrhiza that exhibits antibacterial and antifungal activity, neuroprotective activity, and protective effects against chemotherapeutic drug-induced hepatotoxicity and nephrotoxicity.1 Xanthorrhizol suppresses the expression of ornithine decarboxylase, cyclooxygenase-2, and inducible nitric oxide synthase at concentrations as low as 0.3 μM.2,3 It exhibits an anti-metastasis effect and anti-tumor promoter activity in various mouse models of carcinogenesis.2,3 Xanthorrhizol inhibits the proliferation of human colon cancer HCT116 cells with an IC50 value of 54.8 μM by inducing cell cycle arrest and apoptosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, Y.J., Park, K.K., Chung, W.Y., et al. Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. J. Pharmacol. Sci. 111(3), 276-284 (2009).

    2. Chung, W.Y., Park, J.H., Kim, M.J., et al. Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-κB. Carcinogenesis 28(6), 1224-1231 (2007).

    3. Choi, M.A., Kim, S.H., Chung, W.Y., et al. Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model. Biochem. Biophys. Res. Commun. 326(1), 210-217 (2005).