For immunochemical detection of MBOAT5
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MBOAT5 Polyclonal Antibody

Item No. 14699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • LPCAT3
  • LPLAT 5
  • Lysophosphatidylcholine acyltransferase 3
  • Lysophosphatidylserine acyltransferase
  • Lysophospholipid acyltransferase 5
  • OACT5
Immunogen
Synthetic peptide from the C-terminal region of human MBOAT5
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, conaining 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
FC and IF
Species Reactivity
(+) Human
UniProt Accession №
Q6P1A2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $440

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    Product Description

    Membrane bound O-acyl transferases (MBOATs) are a group of conserved, multiple transmembrane spanning enzymes involved in many biological functions including lipid biosynthesis, embryogenesis, nutrient sensing, and membrane lipid remodeling. This group of proteins is associated with pathologies such as diabetes, obesity, atherosclerosis and Alzheimer’s disease.1 MBOAT5 catalyzes the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity), and favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. MBOAT5 is a major enzyme contributing to LPCAT activity in the liver.2 MBOAT5 and other lysophospholipid acyltransferases (LPLATs), are involved in the Lands cycle by catalyzing the reacylation of phospholipid remodeling.3 Cayman’s MBOAT5 Polyclonal Antibody can be used for flow cytometry and immunofluorescence applications. The antibody recognizes MBOAT5 from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, C.C.Y., Sun, J., and Chang, T.Y. Membrane-bound O-acyltransferases (MBOATs). Front. Biol. 6(3), 177-182 (2011).

    2. Zhao, Y., Chen, Y.Q., Bonacci, T.M., et al. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. The Journal of Biological Chemisty 283(13), 8258-8265 (2007).

    3. Gijón, M.A., Riekhof, W.R., Zarini, S., et al. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. The Journal of Biological Chemisty 283(44), 30235-30245 (2008).