For immunochemical detection of JARID1B/PLU1
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JARID1B/PLU1 (C-Term) Polyclonal Antibody

Item No. 14701

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CT31
  • Jumonji/ARID domain-containing protein 1B
  • KDM5B
  • Lysine-specific Demethylase 5B
  • RBBP2H1
Immunogen
Synthetic peptide from the C-terminal region of human JARID1B/PLU1
Formulation (Request formulation change)
Peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4 with 50% glycerol, 0.1% BSA and 0.02% sodium azide
Host
Rabbit
Applications
FC and ICC
Species Reactivity
(+) Human JARID1B/PLU1
UniProt Accession №
Q9UGL1
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $347

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    Product Description

    Jumonji AT rich interactive domain 1B (JARID1B) nuclear proteins are potential histone demethylases.1,2 JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression.1 JARID1B acts as a transcriptional co-repressor of two developmental transcription factors, PAX-9 and BF1, which are crucial for organogenesis in mouse embryo.3 JARID1B has also been shown to interact directly with histone deacetylase.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamane, K., Tateishi, K., Klose, R.J., et al. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol. Cell 25(6), 801-812 (2007).

    2. Barrett, A., Madsen, B., Copier, J., et al. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen? Int. J. Cancer 101(6), 581-588 (2002).

    3. Tan, K., Shaw, A.L., Madsen, B., et al. Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. The Journal of Biological Chemisty 278(23), 20507-20513 (2003).

    4. Barrett, A., Santangelo, S., Tan, K., et al. Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int. J. Cancer 121(2), 265-275 (2007).