A serine protease inhibitor
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Aprotinin

Item No. 14716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
9087-70-1
Synonyms
  • Bovine Pancreatic Trypsin Inhibitor
  • BPTI
Molecular Formula
C284H432N84O79S7
Formula Weight
6511.4
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly SolubleDMSO: Slightly SolubleEthanol: Slightly Soluble
SMILES
[H]N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(N4CCC[C@H]4C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C5=O)CC(O)=O)=O)=O)C)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)C)=O)=O)CS)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CC8=CC=CC=C8)=O)=O)=O)CSSC[C@H](N5)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@@H](C)O)([H])C9=O)=O)=O)CCSC)=O)=O)=O)=O)C)=O)=O)C)=O)=O)CC%10=CC=C(O)C=C%10)=O)CC%11=CC=CC=C%11)=O)CC%12=CC=C(O)C=C%12)=O)=O)=O)=O)=O)C)=O)=O)CS)=O)=O)=O)=O)CC%13=CC=C(O)C=C%13)=O)=O)=O)=O)=O)CSSC[C@H](N9)C(NCC(NCC(N[C@H](C(O)=O)C)=O)=O)=O)=O)CC%14=CC=CC=C%14)=O)CC(O)=O)=O)=O
InChi Code
InChI=1S/C284H434N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(414)322-149(14)230(398)326-168(62-35-39-98-285)234(402)319-146(11)227(395)314-132-215(385)324-181(113-141(3)4)247(415)355-200-138-453-454-139-201(357-257(425)194(126-219(391)392)348-241(409)178(92-95-217(387)388)329-231(399)150(15)323-260(428)196(134-369)353-240(408)171(65-38-42-101-288)332-249(417)184(115-155-53-27-23-28-54-155)343-254(422)193(125-210(293)380)347-255(423)192(124-209(292)379)345-238(406)173(67-45-104-308-281(298)299)330-237(405)170(64-37-41-100-287)327-228(396)147(12)321-236(404)172(66-44-103-307-280(296)297)334-261(429)197(135-448)325-214(384)131-313-211(381)128-315-232(400)183(119-159-75-83-163(373)84-76-159)351-270(438)221(143(7)8)359-258(426)190(118-158-59-33-26-34-60-158)352-273(441)225(153(18)371)364-245(413)177(335-263(200)431)91-94-207(290)377)264(432)336-179(97-112-450-20)242(410)331-176(70-48-107-311-284(304)305)244(412)363-226(154(19)372)274(442)358-199(233(401)316-129-212(382)312-130-213(383)318-151(16)278(446)447)137-451-452-140-202(356-253(421)186(117-157-57-31-25-32-58-157)344-256(424)195(127-220(393)394)350-267(435)204-72-50-109-366(204)275(443)167(289)61-43-102-306-279(294)295)265(433)339-182(114-142(5)6)248(416)338-180(93-96-218(389)390)276(444)368-111-52-74-206(368)277(445)367-110-51-73-205(367)268(436)349-189(122-162-81-89-166(376)90-82-162)259(427)362-224(152(17)370)269(437)317-133-216(386)365-108-49-71-203(365)266(434)354-198(136-449)262(430)333-169(63-36-40-99-286)235(403)320-148(13)229(397)328-175(69-47-106-310-283(302)303)243(411)360-223(145(10)22-2)272(440)361-222/h23-34,53-60,75-90,141-154,167-206,221-226,369-376,448-449H,21-22,35-52,61-74,91-140,285-289H2,1-20H3,(H2,290,377)(H2,291,378)(H2,292,379)(H2,293,380)(H,312,382)(H,313,381)(H,314,395)(H,315,400)(H,316,401)(H,3
InChi Key
RWLBZZCCAZDWSE-LPYSRVMUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    25 mg

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    50 mg

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    100 mg

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    Product Description

    Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM).1 It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 µM).1 Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 µM, respectively.2 Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Capasso, C., Rizzi, M., Menegatti, E., et al. Crystal structure of the bovine α-chymotrypsin:Kunitz inhibitor complex. An example of multiple protein:protein recognition sites. J. Mol. Recognit. 10(1), 26-35 (1997).

    2. Venturini, G., Colasanti, M., and Ascenzi, P. Aprotinin, the first competative protein inhibitor of NOS activity. Biochem. Biophys. Res. Commun. 249(1), 263-265 (1998).