A potent, metabolically stable analog of PGE2
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15(S)-15-methyl Prostaglandin E2

Item No. 14730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S-dihydroxy-15-methyl-9-oxo-prosta-5Z,13E-dien-1-oic acid
CAS Number
35700-27-7
Synonyms
  • 15(S)-15-methyl PGE2
Molecular Formula
C21H34O5
Formula Weight
366.5
Purity
≥98%
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O[C@H]1[C@H](/C=C/[C@](O)(C)CCCCC)[C@@H](C/C=C\CCCC(O)=O)C(C1)=O
InChi Code
InChI=1S/C21H34O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-17,19,23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,19-,21+/m1/s1
InChi Key
XSGQFHNPNWBVPT-DSFPJDRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    15(S)-15-methyl Prostaglandin E2 (15(S)-15-methyl PGE2) is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound.1 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70(3), 359-370 (1976).

    2. Kimball, F.A., Kirton, K.T., Spilman, C.H., et al. Prostaglandin E1 specific binding in human myometrium. Biol. Reprod. 13(4), 482-489 (1975).