An irreversible inhibitor of IκBα phosphorylation
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BAY 11-7085

Item No. 14795

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
CAS Number
196309-76-9
Molecular Formula
C13H15NO2S
Formula Weight
249.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): Insolulble
λmax
205, 252 nm
SMILES
CC(C)(C)C1=CC=C(S(/C=C/C#N)(=O)=O)C=C1
InChi Code
InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
InChi Key
VHKZGNPOHPFPER-ONNFQVAWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $63

    Add

    10 mg

    $98

    Add

    25 mg

    $229

    Add

    50 mg

    $423

    Add
    Product Description

    BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).1 It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.1,2,3 BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pierce, J.W., Schoenleber, R., Jesmok, G., et al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. The Journal of Biological Chemisty 272(34), 21096-21103 (1997).

    2. Scaife, C.L., Kuang, J., Wills, J.C., et al. Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: Implications for metastasis. Cancer Res. 62(23), 6870-6878 (2002).

    3. Di Giuseppe, M., Gambelli, F., Hoyle, G.W., et al. Systemic inhibition of NF-κB activation protects from silicosis. PLoS One 4(5), e5689 (2009).

    4. Hu, X., Janssen, W.E., Moscinski, L.C., et al. An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61(16), 6290-6296 (2001).

    Product Citations

    Li, L.X., Fan, L.X., Zhou, J.X., et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J. Clin. Invest. 127(7), 2751-2764 (2017).