An irreversible inhibitor of IκBα phosphorylation
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BAY 11-7085

Item No. 14795

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
CAS Number
196309-76-9
Molecular Formula
C13H15NO2S
Formula Weight
249.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): Insolulble
λmax
205, 252 nm
SMILES
CC(C)(C)C1=CC=C(S(/C=C/C#N)(=O)=O)C=C1
InChi Code
InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
InChi Key
VHKZGNPOHPFPER-ONNFQVAWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

    $98

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    25 mg

    $229

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    50 mg

    $423

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    Product Description

    BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).1 It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.1,2,3 BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pierce, J.W., Schoenleber, R., Jesmok, G., et al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. The Journal of Biological Chemisty 272(34), 21096-21103 (1997).

    2. Scaife, C.L., Kuang, J., Wills, J.C., et al. Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: Implications for metastasis. Cancer Res. 62(23), 6870-6878 (2002).

    3. Di Giuseppe, M., Gambelli, F., Hoyle, G.W., et al. Systemic inhibition of NF-κB activation protects from silicosis. PLoS One 4(5), e5689 (2009).

    4. Hu, X., Janssen, W.E., Moscinski, L.C., et al. An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61(16), 6290-6296 (2001).

    Product Citations

    Li, L.X., Fan, L.X., Zhou, J.X., et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J. Clin. Invest. 127(7), 2751-2764 (2017).